Chief Scientific Officer Pivot Park Screening Centre B.V., Netherlands
Mechanistic and phenotypic MALDI-MS-based cell assays are an emerging technology for compound screening and profiling. Due to its robustness and high-throughput capability it is indispensable for a variety of applications in life sciences, chemical biology and pharmaceutical research, e.g. the discovery of enzyme inhibitors or the characterization of protein-ligand interactions.
This course introduces to MALDI MS and covers recent advances in cell-based assays for the determination of compound uptake or drug actions using MALDI-MS and provides an overview of the modern technology for whole cell phenotyping. This includes an overview of MALDI-MS-based cell assays from its first used in research towards high-throughput applications. Participants will learn how to develop, optimize and validate MS-based cell assays, including tips and tricks in cell-treatment, sample preparation and transfer to the MALDI device, quantification using stable-isotope-labeled standards, MALDI-TOF data acquisition and data analysis. Furthermore, a special focus will be on lab-automation systems mandatory for high-throughput applications.
If You Registered in Advance (Online): Your account information was emailed to the address in your SLAS Europe 2023 Registration record. If you have forgotten your access information, you can have it resent to you by clicking on the 'Lost Your Access Key' under the 'Already a User' login box on this page. If You Registered On-Site at SLAS Europe 2023: The first time you access this site, you will want to create your account by clicking on "Join Now". Once your account is created, your login credentials will be emailed to the address on your profile. This information will need to be retained in order to log back into the system to complete the evaluation and claim your certificate.