For nucleic acids, a workflow demonstrating isolation of DNA and RNA from the same sample is demonstrated, which is scalable to 96-well format and can be fully automated on liquid handlers starting from the deparaffinization step. Isolation of high-quality RNA and DNA from the same sample enables direct comparison of gene expression to DNA mutations and methylation profiles even from scarce material.
Our workflows for FFPE samples allow for comprehensive, scalable and reliable analysis of biomolecules from archived material enabling integral understanding of underlying molecular characteristics of diseases.