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Protein Stable, Leatherhead, UK, has been set up to solve the challenges of protein stability screening in a market where new large molecule therapeutic introductions have outpaced technology development. By introducing the first fully microplate-based screening of native proteins, we have solved the issues of ease of sample handling through the process, higher throughputs with lower sample usage and virtually eliminated expensive consumables. Used either stand-alone or as part of a broader automation strategy, stability screening has now caught up with the rest of the drug discovery pipeline. It can deliver fast, accurate answers to the most stable candidates in construct screening, formulation and lead optimisation.