Automated, label-free MALDI-MS-based cell assays: from feasibility study to high-throughput screening

Mechanistic and phenotypic MALDI-MS-based cell assays are an emerging technology for compound screening and profiling. Due to its robustness and high-throughput capability it is indispensable for a variety of applications in life sciences, chemical biology and pharmaceutical research, e.g. the discovery of enzyme inhibitors or the characterization of protein-ligand interactions.

This course introduces to MALDI MS and covers recent advances in cell-based assays for the determination of compound uptake or drug actions using MALDI-MS and provides an overview of the modern technology for whole cell phenotyping. This includes an overview of MALDI-MS-based cell assays from its first used in research towards high-throughput applications. Participants will learn how to develop, optimize and validate MS-based cell assays, including tips and tricks in cell-treatment, sample preparation and transfer to the MALDI device, quantification using stable-isotope-labeled standards, MALDI-TOF data acquisition and data analysis. Furthermore, a special focus will be on lab-automation systems mandatory for high-throughput applications.

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