Sphere Fluidics is an established Tools company based near Cambridge (UK). Sphere has a range of novel single-cell encapsulation products that perform high-throughput single-cell analysis. Our main platform (Cyto-Mine®) is protected by a comprehensive patent portfolio and, within several hours, can automatically screen up to 40 million single cells in miniaturised aqueous pL volume compartments called picodroplets. These are assayed for single cells that secrete valuable proteins (e.g., antibodies) and imaged (for monoclonality assurance) during subsequent dispensing of “hits”. Cyto-Mine® is enabling, increases throughput and reduces costs and time for biopharmaceutical discovery and development, cell therapy and synthetic biology.